[Skip to the guide](#guide) [NextGen](/) [Compare](/compare/) [Questions](/faq/) [About](/about/) [Guide](/) Beginner questions / SHORT ANSWERS / THE CONTEXT # Start with a question. These NextGen Peptides questions explain the words that can make weight-management research hard to follow. The answers describe compounds and access limits. They do not decide which medicine is appropriate for you. TODAY / U.S. ONLY [Start a Promise Peptides visit for metabolic support](https://mypromise.com/solutions/metabolic-support-fat-loss?utm_source=nextgen&utm_medium=affiliate&utm_campaign=faq&utm_content=hero) Promise Peptides prescribes now. A licensed provider reviews each request and decides whether to prescribe. Not everyone qualifies. Compounded medicines are made to order, not FDA-approved. NextGen may earn money when readers become Promise patients. TARGET STUDY / 03 GLP-1 + GIP + glucagon GLP-1, GIP and glucagon are hormone signals. A receptor is a cell’s signal receiver. Retatrutide acts on three receptor types. 01 ## The questions behind the search. ### What is a peptide? A peptide is a short chain of protein building blocks. The word describes a kind of molecule. It does not tell us whether a particular product is approved, suitable for a person or safe to use. ### What does NextGen mean by a generation? We use generation to count the receptor types a compound acts on. A receptor is a part of a cell that receives a signal. The count is a reading aid, not an official approval category or a ranking. ### What do GLP-1 and GIP mean here? They are names for hormone signals in the body. Hormones carry messages. Semaglutide acts on the GLP-1 receptor. Tirzepatide acts on GIP and GLP-1 receptors. The initials describe the targets, not a personal treatment plan. ### What is a triple agonist? An agonist is a compound that activates a receptor. A triple agonist acts on three receptor types. Retatrutide's targets are GLP-1, GIP and glucagon. Having three targets does not change the fact that retatrutide remains investigational. ### Is retatrutide FDA-approved? No. Retatrutide is investigational and in Phase 3 clinical trials, which are studies in people. It has no approved use and is not available by prescription. This guide does not predict an approval date. ### Can I get retatrutide through the links here? Promise has no retatrutide product. Its links here are for metabolic support, semaglutide or tirzepatide. They are not a route to retatrutide. ### Are semaglutide and tirzepatide approved? FDA-approved products containing those ingredients exist. FDA is short for the U.S. Food and Drug Administration. Approval is specific to a finished medicine. Compounded semaglutide and compounded tirzepatide are not FDA-approved. ### What does compounded mean? It means a medicine is made to order. A compounded medicine is not FDA-approved. The FDA does not review its safety, quality or effectiveness before it is sold. A pharmacy licence is different from product approval. ### Why is a research-only label a concern? Some products are marked “not for human use.” An order does not include a licensed provider reviewing your health. The FDA warns that unapproved products sold with research labels can have unknown quality and may be harmful. ### Is NextGen a shop or a medical service? NextGen is a plain-language guide. It does not sell medicines, arrange prescriptions or assess medical questions. Its links point to a separate service. The link itself is not a health review or an offer of care. ### Is Promise prescribing semaglutide and tirzepatide now? Promise prescribes semaglutide and tirzepatide now through licensed U.S. providers. A provider reviews every request and decides whether to prescribe. Not everyone qualifies. A product page is not a promise of a prescription. ### Is the linked route available outside the United States? Promise is for U.S. patients only. Availability varies by state and by treatment. Reading a page or starting a request does not make care available in another country. ### What does LegitScript certification mean? Promise is LegitScript-certified. This is a private check of business standards, not FDA approval or a rating of medical care. Certification does not replace a provider's review or tell a person which medicine to choose. 02 ## Reading behind this page. 01 / [FDA: what compounding means](https://www.fda.gov/drugs/human-drug-compounding/compounding-and-fda-questions-and-answers) Explains medicines made to order and how they differ from FDA-approved products. 02 / [FDA: risks of compounded medicines](https://www.fda.gov/drugs/human-drug-compounding/understanding-risks-compounded-drugs) Explains that compounded medicines do not receive FDA approval before they are sold. 03 / [FDA: concerns about unapproved GLP-1 drugs](https://www.fda.gov/drugs/drug-alerts-and-statements/fdas-concerns-unapproved-glp-1-drugs-used-weight-loss) Covers unapproved products, including retatrutide, sold with research-only labels. ## Take the next question to a licensed route. Promise prescribes semaglutide and tirzepatide now through licensed U.S. providers. A provider reviews every request and decides whether to prescribe. Not everyone qualifies. TODAY / U.S. ONLY [Start a Promise Peptides visit for metabolic support](https://mypromise.com/solutions/metabolic-support-fat-loss?utm_source=nextgen&utm_medium=affiliate&utm_campaign=faq&utm_content=closing) Promise Peptides prescribes now. A licensed provider reviews each request and decides whether to prescribe. Not everyone qualifies. Compounded medicines are made to order, not FDA-approved. NextGen may earn money when readers become Promise patients. [Retatrutide](/retatrutide/) [Tirzepatide](/tirzepatide/) [Semaglutide](/semaglutide/) [About](/about/) [References](/references/) [Contact](/contact/) [Promise Peptides: weight visit](https://mypromise.com/products?utm_source=nextgen&utm_medium=affiliate&utm_campaign=faq&utm_content=footer) NextGen may earn money when readers become Promise patients. NextGen is not affiliated with any company that has used the name NextGen Peptides or Next Gen Peptides. NextGen puts peptide questions into plain words; it is a guide, not a clinic, pharmacy or seller. Facts reviewed 8 October 2026 [Read as Markdown](/faq/index.md)